Techniques for performing frequency hopping in a wireless network are described. In an aspect, frequency hopping may be performed based on both cell identity (ID) and system time information. In one design, a user equipment (UE) may determine a cell ID of a cell and may obtain system time information for the cell. The UE may determine resources to use for transmission with frequency hopping based on the cell ID and the system time information. In one design, the UE may initialize a PN generator in each radio frame with an initial value determined based on the cell ID and a system frame number (SFN) for the radio frame. The UE may determine the resources to use for transmission based on a hopping function, a mirroring function, and a PN sequence from the PN generator. The UE may send a transmission on the resources to the cell.